Blockers of gsk3 for the prevention and treatment of pemphigus vulgaris
Authors
Mueller EJ
Institution
Univeristy of Bern
Country
Switzerland
Year
2008
Journal
WIPO Patent Application WO/2008/012031
Abstract
The invention relates to a method of preventing and treating pemphigus vulgaris comprising administering a GSK3 blocker, and the use of such blockers in said prevention and treatment and in the manufacture of medicaments for preventing and treating pemphigus vulgaris. In particular the invention relates to a method of preventing and treating pemphigus vulgaris comprising administering a GSK3β blocker, and the use of such blockers in said prevention and treatment and in the manufacture of medicaments for preventing and treating pemphigus vulgaris. Preferred is the use of GSK3β blockers which are selective for GSK3β, i.e. which selectively reduce enzyme activity of GSK3β but not to a reasonable extent of GSK3α.