Accelerate corneal & ocular research with CELLnTEC’s chemically defined, animal-component-free media, primary human corneal epithelial cells, and advanced 2D/3D ocular surface models. Our robust and reproducible systems recreate in vivo-like ocular microenvironments for high-content drug screening, toxicity testing, and translational eye research, enabling improved predictive outcomes in eye biology and therapeutic development.
With rising cases of irreversible vision loss in aging societies, diseases such as macular degeneration and retinitis pigmentosa demand next-generation disease modeling and corneal regeneration studies. CELLnTEC supports innovative in vitro platforms for studying blinding disorders, advancing regenerative approaches, and accelerating discovery in ophthalmic research and biopharma development.
Our epithelial & melanocyte proliferation media and specialty formulations enable efficient isolation, 2D expansion, co-culture, differentiation, and long-term homeostasis of ocular cells. Designed for donor consistency and scalable performance, these systems empower ocular researchers to investigate epithelial biology, pigmentation, and functional ocular cell responses with high viability and reproducibility.
CELLnTEC’s 3D media and iPSC epithelial differentiation media drive the development of physiologically relevant in vitro models for safety pharmacology and mechanistic studies. Our 2D/3D ocular surface models reduce experimental variability while enhancing biological relevance, supporting reliable ocular testing workflows from early discovery to preclinical decision-making.
Our animal-component-free media and human-relevant ocular models actively support the 3R principle (Replacement, Reduction, Refinement) by replacing animal-derived components, reducing reliance on animal testing, and refining predictive in vitro systems. These advanced platforms contribute to the development of Advanced Therapy Medicinal Products (ATMPs), including cell and gene therapies for ocular regeneration, facilitating regulatory-aligned, translational ophthalmic innovation.
2D corneal epithelial monolayers for barrier function and permeability studies.
Supports primary and iPSC-derived corneal epithelial and corneal limbal epithelial cells within the same ecosystem.
3D corneal epithelial models for advanced ocular surface biology and stratification assays.
Ocular surface disease modeling.
High-throughput in vitro ophthalmic drug screening and mechanistic studies.
Gene and cell therapy studies for vision recovery.
Barrier integrity and corneal wound-healing assays.
Corneal innate immune response assays.
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Media composition that maximizes viable cell yield from limited human corneal tissue.
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Maintains high numbers of undifferentiated corneal epithelial progenitors during expansion
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Referenced in many publications exploring limbal stem cells, ocular surface reconstruction, and corneal regeneration.
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Supports an increased number of cell doublings while preserving corneal epithelial function and differentiation capacity.
Primary epithelial cells growing in CnT-NX-EX display a highly proliferative phenotype. For differentiation experiments, it is recommended to switch to the CnT-PR-D or CnT-PR-3D differentiation media.
