CnT-Prime Melanocyte Differentiation Medium

CnT-PR-MD

Frozen medium

500 mL

CHF 260.00

Description

CnT-PR-MD is a fully defined, ready-to-use medium specifically formulated to promote melanocyte differentiation, melanin expression, and dendricity. Unlike standard melanocyte media, which provide mixed signals for both proliferation and melanin expression, CnT-PR-MD focuses exclusively on differentiation, creating an environment that mimics in vivo conditions. This targeted approach enables melanocytes to perform their natural functions optimally.
As a result, CnT-PR-MD delivers 2.5 times more melanin and increased dendricity compared to the proliferative CnT-40 medium. The formulation is free of PMA, TPA, and antibiotics/antimycotics, and is provided fully supplemented and frozen for convenience.
CnT-PR-MD can also be used in conjunction with CnT-PR-MH (Melanocyte Homeostasis Medium) when conducting melanocyte whitening assays.

Category Media

Highlights

1

Designed for melanocyte differentiation

Specifically formulated to promote differentiation and dendricity in primary melanocytes

2

Boost melanin expression

Drives ~2.5× higher melanin production compared with proliferative conditions

3

Low serum formulation

Low-serum medium without PMA or TPA, minimizing artificial stimulation for more physiologically relevant cell behavior.

4

Maximize standardization and convenience

Fully supplemented, one bottle ready-to-go. Maximize standardization and convenience. Minimize variability and error

CnT-PR-MD

CnT-40

Tissue type

Skin, Eye

Skin, Eye

Cell type

Melanocytes

Melanocytes

Species

Human, may also work for other species

Human, may also work for other species

Workflow Steps

Differentiation

Isolation, Proliferation

Serum Level

< 1 % bovine serum

< 1 % bovine serum

BPE Level

BPE-free

BPE-free

ACF Status

Contains animal components

Contains animal components

Chemically defined

No

No

Clinically upgradable

–

–

Volume

500 mL

500 mL

Component(s)

–

–

Quality Level

Research Grade

Research Grade

Scientific Literature

Melissa Crawford et al.

(2020)

— J Investig Dermatol

Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin

Read publication >

Downloads

CnT-Prime Melanocyte Differentiation Medium Datasheet

Download

CnT-Prime Melanocyte Differentiation Medium SDS

Download

2D differentiation of Melanocytes and total melanin assay

Download

General thawing, passaging, and freezing protocol

Download

Related Products

CnT-PR-MD has been optimized for differentiation of melanocytes. For proliferation of melanocytes, it is recommended to use CnT-40.

CnT-40

Selective isolation and rapid expansion of primary epidermal melanocytes.

CnT-PR-MH

Low growth factor medium used for homeostatic maintenance of melanocytes.

HEMas

Normal human epidermal melanocytes, isolated from adult donor material, cryo preserved at early passage.

HEMns

Normal human epidermal melanocytes, isolated from juvenile donor material, cryo preserved at early passage.

CnT-PR-KM

2D co-culture of keratinocytes and melanocytes

PR3D-K-50

Contains the media and inserts needed to establish 3D epidermal models with improved differentiation and barrier function in your own lab.

CnT-PR-ECM

Encouraging high secretion of extra cellular matrix proteins from stromal cells.

CnT-PR-D

2D differentiation of epithelial cells in a chemically defined medium.

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