Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer
Authors
Varun Chalivendra, Krishna Latha Kanchi, Michael D. Onken, Ashley E. Winkler, Elaine Mardis, Ravindra Uppaluri
Institution
Department of Otolaryngology and The Genome Institute, Washington University School of Medicine in Saint Louis, Department of Otolaryngology, United States
Country
United States
Year
2014
Journal
Genomics Data
Abstract
To investigate the molecular basis underlying aggressive behavior in oral squamous cell carcinoma (OSCC), the
laboratory developed a carcinogen-induced mouse oral cancer (MOC) cell line model that encompasses the
growth and metastasis spectrum of its human counterpart. It was performed next-generation sequencing (NGS)
and gene expression microarray profiles to explore the genomic and transcriptional backgrounds of the differential MOC
line phenotypes, as well as, the cross-species relevance of the model. Here it is describe the comparative
analysis of NGS (www.ncbi.nlm.nih.gov/biosample?LinkName=bioproject_biosample_all&from_uid=247825)
and expression microarray (www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE50041) data from the MOC
lines and corresponding human data, as described in the recent publication