Publications

Se-jeong Kim et al.

(2025)

— Adv Healthcare Mater

A Bioengineered Model of the Human Cornea for Preclinical Assessment of Human Ocular Exposure to Environmental Toxicants

Angela L. Maloney et al.

(2025)

— Front Microbiomes

A Multi-Strain Human Skin Microbiome Model Provides a Testbed for Disease Modeling

E. Cate Wisdom et al.

(2025)

— Bioengineering

A Novel Approach to Pattern Dermal Papilla Spheroids in Dermal-Epidermal Composites Using Non-Adherent Microwell Arrays

Marla Dubau et al.

(2025)

— J Tissue Eng

Development of an iPSC-derived immunocompetent skin model for identification of skin sensitizing substances

Omera Bi et al.

(2025)

— Exp Dermatol

Do Melanocytes Have a Role in Controlling Epidermal Bacterial Colonisation and the Skin Microbiome?

Ricardo Fróis-Martins et al.

(2025)

— Nat Microbiol

Dynamic expression of candidalysin facilitates oral colonization of Candida albicans in mice

Alessia Cavallo et al.

(2025)

— Front Physiology

Effects of Th1/Th17 and Th2 cytokines on lipid metabolism in differentiated keratinocytes

Rima Nuwayhid et al.

(2025)

— Front Bioeng Biotechnol

Engineering a 3D wounded skin equivalent to study early inflammatory and regenerative responses in vitro

Jin Hwan Kim et al.

(2025)

— Free Radic Biol Med

Exopolysaccharide from Lacticaseibacillus rhamnosus IR06 as a potential postbiotics attenuates photoaging through regulation of MAPK and NF-κB signaling

Justin C. Rudd et al.

(2025)

— Nat Commun

Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier

Mukta Basu et al.

(2025)

— Cell Death Disease

Genes driving three-dimensional growth of immortalized cells and cancer

Tong Xie et al.

(2025)

— Cosmetics

Human Induced Pluripotent Stem Cells-Derived Reconstructed Epidermal Skin Model as an Alternative Model for Skin Irritation

Shinobu Nakanishi et al.

(2025)

— STAR Protoc

Protocol for odorant-binding protein 2A gene knockdown by dual siRNA transfection in a three-dimensional human epidermal equivalent model

Hyewon Shin et al.

(2025)

— PLoS One

Skin irritation testing using human iPSCs derived 3D skin equivalent model

George H. Hatton et al.

(2025)

— Sci Adv

Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation

Taeeun Kim et al.

(2025)

— Polymers

Wound Healing in Human Skin Equivalents Reconstructed with Biopolymers Under Fine-Dust Exposure

Cl�ment Quintard et al.

(2024)

— Nat Commun

A microfluidic platform integrating functional vascularized organoids-on-chip

K. Brandmair et al.

(2024)

— Toxicology

A novel three-dimensional Nrf2 reporter epidermis model for skin sensitization assessment

Rima Nuwayhid et al.

(2024)

— MDPI biomedicines

A Platform for Testing the Biocompatibility of Implants: Silicone Induces a Proinflammatory Response in a 3D Skin Equivalent

Marla Dubau et al.

(2024)

— J Tissue Eng

Advancing skin model development: A focus on a self-assembled, induced pluripotent stem cell-derived, xeno-free approach

Mayuko Endo et al.

(2024)

— Bioscience, Biotechnology, Biochem

Analysis on promotive effect of rocking culture on keratinocyte differentiation in 3-dimensional reconstitution human epidermis

Hae Jin Lee et al.

(2024)

— Int J Radiation Biol

Comparison of Cellular Responses to Ionizing Radiation in Keratinocytes Isolated from Healthy Donors and Type II Diabetes Patients

Dina Mikimoto et al.

(2024)

— Biofabrication

Culture insert device with perfusable microchannels enhances in vitro skin model development and barrier function assessment

Maitreyi Rathod et al.

(2024)

— J Cell Biol

DPM1 modulates desmosomal adhesion and epidermal differentiation through SERPINB5

Lisa M. Sevilla et al.

(2024)

— Cell Death Disease

Glucocorticoid receptor controls atopic dermatitis inflammation via functional interactions with P63 and autocrine signaling in epidermal keratinocytes

Farah Mansour et al.

(2024)

— Front Cell Developmental Biol

Immortalization of patient-derived lip cells for establishing 3D lip models

Julia Scheurer et al.

(2024)

— Disease Models & Mechanisms

Inflammatory skin disease modeling using 3D human skin equivalents

Enrica Flori et al.

(2024)

— Cells

JAK/STAT Inhibition Normalizes Lipid Composition in 3D Human Epidermal Equivalents Challenged with Th2 Cytokines

Kenji Namoto et al.

(2024)

— Cell Stem Cell

NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo

Katharina Kaiser et al.

(2024)

— Tissue Eng Part C: Methods.

Novel Chip for Applying Mechanical Forces on Human Skin Models Under Dynamic Culture Conditions

Yilong Zhou et al.

(2024)

— Cell

RNA damage compartmentalization by DHX9 stress granules

Tong Xie et al.

(2024)

— Cosmetics

Skin Care Function of Lactoferrin Was Characterized Using Recombinant Human Epidermal Model

Stefan Hainzl et al.

(2024)

— J Translational Med

Splicing Modulation via Antisense Oligonucleotides in Recessive Dystrophic Epidermolysis Bullosa

Jos P.H. Smits et al.

(2024)

— J Investig Dermatol

The Aryl Hydrocarbon Receptor Regulates Epidermal Differentiation through Transient Activation of TFAP2A

Hua Li et al.

(2024)

— J Cell Sci

The RhoGAP ARHGAP32 interacts with desmoplakin, and is required for desmosomal organization and assembly

Natalia Fern�ndez-Parejo et al.

(2024)

— Sci Rep

VAV2 orchestrates the interplay between regenerative proliferation and ribogenesis in both keratinocytes and oral squamous cell carcinoma

Carlos Flores et al.

(2023)

— Sci Adv

A human urothelial microtissue model reveals shared colonization and survival strategies between uropathogens and commensals

Daejin Min et al.

(2023)

— Skin Res & Technol

A novel optical coherence tomography-based in vitro method of anti-aging skin analysis using 3D skin wrinkle mimics

Nazila V. Jafari et al.

(2023)

— Front Cell Infection Microbiol

An immunoresponsive three-dimensional urine-tolerant human urothelial model to study urinary tract infection

Ai Ota et al.

(2023)

— J Biol Chem

Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides

Ruth Jinfen Chai et al.

(2023)

— Int J Bioprinting

Developing a bioink for single-step deposition and maturation of human epidermis

Yuki Umino et al.

(2023)

— Skin Res & Technol

Effect of red light on epidermal proliferation and mitochondrial activity

Nydia C. De La Cruz et al.

(2023)

— J Virology

Ex Vivo Infection of Human Skin Models with Herpes Simplex Virus 1: Accessibility of the Receptor Nectin-1 during Formation or Impairment of Epidermal Barriers Is Restricted by Tight Junctions

Danique A. van der Krieken et al.

(2023)

— iScience

Gram-positive anaerobic cocci guard skin homeostasis by regulating host-defense mechanisms

Maria S. Shutova et al.

(2023)

— iScience

Inflammation modulates intercellular adhesion and mechanotransduction in human epidermis via ROCK2

Tanja Grossmann et al.

(2023)

— PLoS One

Introducing a new type of alternative laryngeal mucosa model

Jos P.H. Smits et al.

(2023)

— J Investig Dermatol

Investigations into the FLG Null Phenotype: Showcasing the Methodology for CRISPR/Cas9 Editing of Human Keratinocytes

Haruka Hakoi et al.

(2023)

— Biochimie

Lysophospholipase D from Thermocrispum limits psoriatic inflammation by hydrolyzing epidermal lysoplasmalogen produced by group IIF secreted phospholipase A2

Gijs Rikken et al.

(2023)

— Microbiome

Novel methodologies for host-microbe interactions and microbiome-targeted therapeutics in 3D organotypic skin models

Wei Long Ng et al.

(2023)

— Bio-Design Manufacturing

Polyvinylpyrrolidone-based bioink: influence of bioink properties on printing performance and cell proliferation during inkjet-based bioprinting

Xi Huang et al.

(2023)

— J Intelligent Manufacturing

Predicting the number of printed cells during inkjet-based bioprinting process based on droplet velocity profile using machine learning approaches

Yan Gao et al.

(2023)

— Cell Death Discovery

SARS-CoV-2 infection causes periodontal fibrotic pathogenesis through deregulating mitochondrial beta-oxidation

Claudia Fierro et al.

(2023)

— Nat Commun

The long non-coding RNA NEAT1 is a ΔNp63 target gene modulating epidermal differentiation

Keisuke Imafuku et al.

(2023)

— Cell proliferation

Zonula occludens-1 distribution and barrier functions are affected by epithelial proliferation and turnover rates

Hyung-Su Kim et al.

(2023)

— Sci Rep

β-endorphin suppresses ultraviolet B irradiation-induced epidermal barrier damage by regulating inflammation-dependent mTORC1 signaling

Gijs Rikken et al.

(2022)

— Int J Mol Sci

Carboxamide Derivatives Are Potential Therapeutic AHR Ligands for Restoring IL-4 Mediated Repression of Epidermal Differentiation Proteins

Sophie Domingues et al.

(2022)

— Cells

Clinical Grade Human Pluripotent Stem Cell-Derived Engineered Skin Substitutes Promote Keratinocytes Wound Closure In Vitro

Cecilia Koskinen Holm et al.

(2022)

— Int J Mol Sci

Engineering a 3D In Vitro Model of Human Gingival Tissue Equivalent with Genipin/Cytochalasin D

Bing (Catherine) Wu et al.

(2022)

— Cells

Host Response of Human Epidermis to Methicillin-Resistant Staphylococcus aureus Biofilm Infection and Synthetic Antibiofilm Peptide Treatment

Julien Coutier et al.

(2022)

— J Investig Dermatol

Human-Induced Pluripotent Stem Cell-Derived Keratinocytes, a Useful Model to Identify and Explore the Pathological Phenotype of Epidermolysis Bullosa Simplex

Manuel Chac�n et al.

(2022)

— Bioelectrochemistry

Impedance-based non-invasive assay for ocular damage prediction on in vitro 3D reconstructed human corneal epithelium

Hirofumi Teshima et al.

(2022)

— FASEB J

Involvement of hypoxia inducible factor activity in inevitable air-exposure treatment upon differentiation in a three-dimensional keratinocyte culture

Juewon Kim et al.

(2022)

— Biomedicine & Pharmacotherapy

Kaempferol tetrasaccharides restore skin atrophy via PDK1 inhibition in human skin cells and tissues: Bench and clinical studies

Zhikai Wang et al.

(2022)

— Nat Commun

Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis

Joleen P. Z. Goh et al.

(2022)

— Immunol inflammation

The human pathobiont Malassezia furfur secreted protease Mfsap1 regulates cell dispersal and exacerbates skin inflammation

Barbara Russo et al.

(2021)

— Arthritis Rheumatology

Dysfunctional Keratinocytes Increase Dermal Inflammation in Systemic Sclerosis: Results From Studies Using Tissue-Engineered Scleroderma Epidermis

Shinobu Nakanishi et al.

(2021)

— Biochem Biophysical Res Commun

Effects of trans-2-nonenal and olfactory masking odorants on proliferation of human keratinocytes

Nikola Kolundzic et al.

(2021)

— J Invest Dermatol Innovations

Epidermal Basement Membrane Substitutes for Bioengineering of Human Epidermal Equivalents

Ayesha Idrees et al.

(2021)

— 4open

Fundamental in vitro 3D human skin equivalent tool development for assessing biological safety and biocompatibility – towards alternative for animal experiments

Nadezhda A. Evtushenko et al.

(2021)

— Int J Mol Sci

hTERT-Driven Immortalization of RDEB Fibroblast and Keratinocyte Cell Lines Followed by Cre-Mediated Transgene Elimination

Bing (Catherine) Wu et al.

(2021)

— npj Biofilms Microbiome

Human organoid biofilm model for assessing antibiofilm activity of novel agents

Hanna Niehues et al.

(2021)

— J Invest Dermatol Innovations

Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis

Chiara Griffoni et al.

(2021)

— Sci Rep

In vitro skin culture media influence the viability and inflammatory response of primary macrophages

Eleftheria Girousi et al.

(2021)

— Front Cell Developmental Biol

Lack of IRF6 Disrupts Human Epithelial Homeostasis by Altering Colony Morphology, Migration Pattern, and Differentiation Potential of Keratinocytes

Petra Pavel et al.

(2021)

— J Invest Dermatol Innovations

Peroxisomal Fatty Acid Oxidation and Glycolysis Are Triggered in Mouse Models of Lesional Atopic Dermatitis

Ji-Eun Bae et al.

(2021)

— Int J Mol Sci

Primary Ciliogenesis by 2-Isopropylmalic Acid Prevents PM2.5-Induced Inflammatory Response and MMP-1 Activation in Human Dermal Fibroblasts and a 3-D-Skin Model

Junichi Kumamoto et al.

(2021)

— Skin Res & Technol

Substrate membrane bearing close‐packed array of micron‐level pillars incrassates air‐exposed three‐dimensional epidermal equivalent model

Monika Wimmer et al.

(2020)

— Cell Commun Signaling

A cancer stem cell-like phenotype isassociated with miR-10b expression inaggressive squamous cell carcinomas

Yung-Yu Yang et al.

(2020)

— Front Cell Developmental Biol

Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOTCH1, MKI67, OCT4, and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells

Manuel Chac�n et al.

(2020)

— Toxicology Vitro

Development of an in-house reconstructed human epidermis model as an alternative method in skin corrosion assessment

Luis Francisco Lorenzo-Mart�n et al.

(2020)

— Cancers

Drug Vulnerabilities and Disease Prognosis Linked to the Stem Cell-Like Gene Expression Program Triggered by the RHO GTPase Activator VAV2 in Hyperplastic Keratinocytes and Head and Neck Cancer

Wai K. Lau et al.

(2020)

— J Controlled Release

Novel particles conferring eradication of deep tissue bacterial reservoirs for the treatment of chronic urinary tract infection

Daejin Min et al.

(2020)

— Int J Cosmetic Sci

Potential anti-aging effect of chondroitin sulfate through skin regeneration

Jos P.H. Smits et al.

(2020)

— J Investig Dermatol

Targeting the Cutaneous Microbiota in Atopic Dermatitis by Coal Tar via AHR-Dependent Induction of Antimicrobial Peptides

Suvara K. Wattanapitayakula et al.

(2020)

— Acta Pharm.

Ultraviolet B irradiation-induced keratinocyte senescenceand impaired development of 3D epidermal reconstruct

Luis Francisco Lorenzo-Mart�n et al.

(2020)

— Nat Commun

VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma

Patricia Renz et al.

(2019)

— J Cell Mol Med

Arginine‐ but not alanine‐rich carboxy‐termini trigger nuclear translocation of mutant keratin 10 in ichthyosis with confetti

Nicolas Mercado et al.

(2019)

— Nat Commun

IRF2 is a master regulator of human keratinocyte stem cell fate

Katharina Bitschar et al.

(2019)

— Nat Commun

Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors

Nanna Fyhrquist et al.

(2019)

— Nat Commun

Microbe-host interplay in atopic dermatitis and psoriasis

Yuki Tanabe et al.

(2019)

— FEBS J

Studies on differentiation-dependent expression and activity of distinct transglutaminases by specific substrate peptides using three-dimensional reconstituted epidermis

Harry Horsley et al.

(2018)

— Sci Rep

A urine-dependent human urothelial organoid offers a potential alternative to rodent models of infection

Yusuke Tanaka et al.

(2018)

— Exp Cell Res

Characterization of distal airway stem-like cells expressing N-terminally truncated p63 and thyroid transcription factor-1 in the human lung

Anni Sorkio et al.

(2018)

— Biomaterials

Human stem cell based corneal tissue mimicking structures using laser-assisted 3D bioprinting and functional bioinks

Faris Alkhilaiwi et al.

(2018)

— Stem Cell Res Ther

Long-term expansion of primary equine keratinocytes that maintain the ability to differentiate into stratified epidermis

Taishi Komori et al.

(2018)

— Sci Rep

Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium

Luca Mazzone et al.

(2016)

— Pediatric Surg

Successful grafting of tissue-engineered fetal skin

Markus Rimann et al.

(2015)

— J Lab Automation

Standardized 3D Bioprinting of Soft Tissue Models with Human Primary Cells

Ask us a question