Biochemical laboratory

Detoxification Enzymes

Keratinocytes have a well developed system for the processing of xeniobiotics and other external pollutants.

The primary detoxification mechanisms are based on the Phase I and Phase II enzymes.

Phase I enzymes such as the cytochrome P450 family oxidize or reduce the xenobiotic. Phase II enzymes such as glutathione-s-transferase conjugate the foreign chemicals with other polar compounds, prior to excretion.

These enzymes are evaluated with and without active ingredient treatment by ELISA.

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