Advanced In Vitro Models, Refined Media
CELLnTEC’s range of epithelial models are developed using highly refined media designed to select a specific cell population, or deliver a particular behaviour such as proliferation or differentiation/ barrier function.
We are experienced with the use of both human and rodent cells for the establishment of a wide range of 2D and 3D in vitro models.
In 3D, we establish air-lift cultures to generate complete stratification and differentiation of epithelial cells from skin, gingiva, bladder, airway and cornea.
We also culture dermal progenitor cells as spheres in non-adherent culture to better maintain the progenitor cell phenotype and gene-expression profile.
Certain questions are best addressed using ex-vivo tissues, due to the additional cell types present in tissue biopsies.
We can use our established network of tissue suppliers to obtain biospies of a range of epithelial tissue types. These can then be used directly in experimentation with active ingredients, to obtain the closest possible insight into the true in vivo responses.