Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model
Authors
Sung Hoon Lee, Il-Hong Bae, Hyangtae Choi, Hyeong Won Choi, Soojung Oh, Paulo A. Marinho, Dae Jin Min, Dae-Yong Kim, Tae Ryong Lee, Chang Seok Lee, Jongsung Lee
Institution
Amorepacific Corporation R&D Center, Sungkyunkwan University, Suwon
Country
South Korea
Year
2019
Journal
Archives of Dermatological Research
Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease that is not fully understood. Defects in skin barrier function and dysregulation of the Th2 immune response are thought to be pivotal in AD pathogenesis. In this study, we used keratinocytes and AD-like skin equivalent models using Th2 cytokines IL-4 and IL-13. The keratinocytes and AD-like skin model were used to investigate the effect of dipotassium glycyrrhizinate (KG), which is widely used as an anti-inflammatory agent for AD treatment. KG decreased AD-related gene expression in keratinocytes stimulated with Th2 cytokines. KG alleviated AD-like phenotypes and gene expression patterns and inhibited release of AD-related cytokines in the AD-like skin equivalent models. These findings indicate KG has potential effectiveness in AD treatment and AD-like skin equivalent models may be useful for understanding AD pathogenesis.