Japan Science and Technology Agency, CREST, Kawaguchi; Research Institute for Electronic Science, Hokkaido University, Sapporo
Country
Japan
Year
2017
Journal
Journal of Dermatological Science
Abstract
During differentiation in intact epidermis, keratinocytes must exert force on other keratinocytes in order to construct the three-dimensional structure of the epidermis. Further, when a foreign material such as a small splinter, penetrates human skin, it is eventually ejected from the surface of the skin, even if it is not cytotoxic or harmful. However, the mechanisms involved have not been studied. In order to investigate this process, we constructed a three-dimensional epidermal-equivalent system and examined what happens to pieces of nontoxic foreign material (polyester textiles) placed below the living layer.