The mitochondrial respiratory chain is required for organismal adaptation to hypoxia
Authors
Robert B. Hamanaka, Samuel E. Weinberg, Colleen R. Reczek, Navdeep S. Chandel
Institution
Northewestern
Country
United States
Year
2016
Journal
Cell Reports
Abstract
Hamanaka et al. show that loss of
mitochondrial respiratory activity in the
mouse epidermis impairs hypoxic
activation of HIF-1. Since epidermal HIF-1
promotes cutaneous vasodilation and
blood flow during hypoxia and
potentiates the hypoxic response in the
internal organs, mice with loss of TFAMin
the epidermis are unable to induce renal
erythropoietin expression in response to
hypoxia.