- Retention of proliferative progenitors and reduced differentiation
- Extended lifespan of the cells
- Pre-equilibrated in CELLnTEC base chemistry
- Supplied in fully-defined cryopreservation medium to maximize recovery after thawing
Normal human dermal progenitor cells. Isolated from the dermal papilla, cryo-preserved at early passage.
|Content||Vial containing 0.5 million viable cells, frozen|
HDPs human dermal fibroblast progenitors (single donor) are isolated very precisely from the dermal papilla region of the hair follicle. HANDLING INSTRUCTION: This material is of human origin and should therefore be handled as hazardous. Although it has been tested negative for HIV 1, Hepatitis B, and Hepatitis C, treat this material as potentially infectious and use appropriate biocontainment, protective equipment, and other precautions to prevent accidental exposure.
In contrast with generalist dermal fibroblast cultures, this approach delivers a specific fibroblast sub-population, that is enriched with progenitor cells. In vivo, these cells are thought to be responsible for hair follicle induction, and the generation of the important papillary layer of the dermis.
HDP progenitors have a characteristic phenotype and are often found to respond differently to external challenges and treatments than generalist fibroblast populations (such as the HDF cultures).
The HDP cells are also ideally suited to culture as non-adherent spheres in hanging drop culture, which retains expression of a range of progenitor cell markers, including Sox-2.
The HDP fibroblasts are provided cryopreserved in the fully defined CRYO-Defined culture medium, to maximize recovery after thawing.
The thawing, seeding, and passaging protocols are particularly important for optimal cell growth. Please visit our Protocols Page for our recommendations.
The cultures undergo a range of QC tests in our lab before being released for sale and are also covered by our longevity guarantee. Please see the datasheet for details.