Global protein expression differences between matched pairs DCIS/Normal and Invasive/Normal Primary HMEC and other physiological differences
Authors
Minkeu A, Quong JN, Rosenberg AL, Brill KL, Quong AA
Institution
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia
Country
United States
Year
2008
Journal
San Antonio Breast Cancer Symposium (Poster Award Winner)
Abstract
We have successfully established cultures of primary human mammary epithelial cells from various types of breast cancer. The DCIS-derived epithelial cells show a range of growth rates and response to Tamoxifen. We identified numerous proteins with expression patterns different between normal/tumor and invasive/DCIS. Some of the proteins identified are known tumor markers such as S100 protein family members. Further comparison analysis on additional samples is ongoing and will allow us to define markers that could be used in better prognosis for DCIS patients specifically and breast cancer patients in general.
Tissue type
Mammary
Tissue info
Mammary tissue from various breast cancer types (DCIS, stage 1, 2, and 3 Invasive tumor) was obtained from patients along with their matched normal tissue immediately after surgery