Photoageing of the skin is the main consequence of UVA radiation. UVB radiation often triggers an acute skin inflammation known as sunburn. The consequence of DNA damage caused by UVB is the synthesis of different proteins and enzymes. The effects of these proteins, notably prostaglandins and cytokines, lead to dilatation of cutaneous blood vessels and recruitment of inflammatory cells. This, in turn, produces sunburn's characteristic redness, swelling and pain. When the first signs of sunburn appear, the dose of UV radiation which can be accommodated has already been exceeded many times over, and the skin's repair mechanisms are overloaded. CELLIGENT® protects the DNA and supports the repair of UV-induced cell damage. Three active principles are interlocked: a) neutralisation of dangerous oxygen radicals using natural antioxidants, b) reduction of the dose of UV radiation using ingredients with UV-absorbing properties, c) support of DNA repair using a biochemical pre-stage of nucleotides required for this process.
Product use
Human Epidermal Keratinocyte Progenitors from pooled donors were used to establish 3D models. They were irradiated with UV and analyzed for thymie dimers (immunohistochemistry; TT-dimer spcific antibody)
Tissue type
Epidermal
Tissue info
CELLnTEC's human keratinocytes form neonatal foreskin