Atopic dermatitis (AD) is a chronic and relapsing skin disorder characterized by pruritic and dry skin lesions with
allergic inflammation. Recent studies have revealed anti-inflammatory and anti-allergic effects of xanthones in
mangosteen through regulation of the nuclear factor (NF)-jB signaling pathway. Activation of NF-jB signals is
responsible for allergic inflammation in AD. To develop a new preventive therapy for AD, we examined the effects
of the natural medicine, mangosteen rind extract (ME), on AD in a murine model. ME (250 mg/kg per day) was
administrated to NC/Tnd mice, a model for human AD, for 6 weeks to evaluate its preventive effects on AD. We
also confirmed the effects of ME on various immune cell functions. Oral administration of ME prevented the
increase of clinical skin severity scores, plasma total immunoglobulin E levels, scratching behavior, transepidermal
water loss and epidermal hyperplasia in NC/Tnd mice; moreover, no adverse effects were noted. We demonstrated
that ME suppressed thymic stromal lymphopoietin and interferon-c mRNA expression both in vitro and in
vivo. Not only immunoglobulin E production from splenic B cells but also immunoglobulin E-mediated degranulation
of bone marrow-derived cultured mast cells was significantly reduced by the addition of ME to the culture. In
addition, mRNA expression levels of nerve growth factor were decreased in ME-administrated NC/Tnd mice compared
with those of controls. Keratinocyte proliferation was well-controlled by ME application. Oral administration
of ME exhibited its suppressive potential on the early development of AD by controlling inflammation, itch and
epidermal barrier function.
Key words: a-mangostin, atopic dermatitis, mangosteen, rind, thymic stromal lymphopoietin.