Tissue Selective Stearoyl-coa Desaturase 1 Inhibitors and Cell Based Screening Assay for their Identification
Authors
Khairatkar-joshi N, Shah D, Gharat LA, Narayana L
Institution
Glenmark Pharmaceuticals S.A., La Chaux-De-Fonds
Country
Switzerland
Year
2011
Journal
United States Patent Application 20110184027
Abstract
The present invention provides a method of treating a disorder treatable by administering a therapeutically effective amount of a tissue selective Stearoyl-CoA Desaturase 1 (SCD-1) modulator to a subject. In one embodiment, the present invention provides a method of treating a disorder treatable by administering a pharmaceutically effective amount of a tissue selective SCD-1 inhibitor to a subject. The invention also provides whole cell based screening assays to identify agents that selectively modulate the activity of SCD-1. This invention further provides whole cell based screening assays to identify agents that differentially inhibit SCD in different body tissues.