Transcription Factor Inhibitors And Related Compositions, Formulations And Methods
Authors
Li PK, Li C, Lin J
Institution
Center for Childhood Cancer, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, College of Medicine, Columbus
Country
United States
Year
2011
Journal
United States Patent Application 20110212911
Abstract
The present invention provides small molecules useful to affect cancer cells, along with related methods. The present compounds, formulations, kits and methods are useful for a variety of research, diagnostic and therapeutic purposes. STAT3 inhibitors, particularly LLL12, are disclosed. The STAT3 inhibitors are useful to treat breast cancer in general and breast cancer initiating cells in particular.
Tissue type
Pancreatic Duct
Tissue info
Immortalized human pancreatic duct epithelial (HPDE) cells